Long-Term Side Effects of Advil (Ibuprofen)

Advil, known generically as ibuprofen, is a popular over-the-counter medication often used for pain relief, reducing fever, and alleviating inflammation. While it’s effective for short-term use, taking Advil for a long time can have several side effects. It’s important for you to be aware of these if you’re considering long-term use.

Advil Side Effects

Increased Risk of Gastrointestinal Bleeding and Ulcers

One of the most significant risks associated with long-term use of Advil is the development of stomach ulcers and gastrointestinal bleeding. Advil can significantly irritate the stomach lining. With prolonged use, this irritation can lead to the development of ulcers, which are painful sores in the stomach lining, and increase the risk of serious gastrointestinal bleeding. This bleeding can be life-threatening and may occur without warning.

Besides ulcers, long-term Advil use can cause a range of digestive issues, including bloating, gas, and discomfort. These symptoms might seem minor, but they can affect your daily life and overall comfort.

Increased Blood Pressure

The potential increase in blood pressure due to long-term Advil use is a significant concern. High blood pressure is the greatest risk factor for heart disease and stroke. For individuals with existing cardiovascular issues, this risk is even more pronounced.

Heart Attack and Stroke

The link between long-term use of Advil and an increased risk of heart attack or stroke cannot be overstated. This risk may be particularly high for individuals who already have heart disease or risk factors like smoking, diabetes, or high cholesterol.

Chronic Kidney Disease

Prolonged use of Advil can potentially lead to chronic kidney disease (CKD), where your kidneys gradually lose function over time. This condition can progress to kidney failure, which is a serious health concern requiring dialysis or a kidney transplant.

Potential for Liver Damage

Though less common compared to other side effects, Advil can harm your liver, especially when taken in high doses over a long period. Liver damage can be severe and may potentially lead to conditions like hepatitis (inflammation of the liver) or liver failure.

Allergic Reactions and Sensitivities

Some individuals might develop allergic reactions to Advil. These reactions can vary from mild symptoms, like rashes or itching, to severe conditions, like anaphylaxis, which requires immediate medical attention.

Mood Changes

Though not as common, some individuals might experience mood changes with long-term use of Advil. These changes can include symptoms like irritability or depression.

Risks During Pregnancy

Using Advil during pregnancy, particularly in the later stages, can pose risks to the developing fetus. It can affect the baby’s heart and lungs and may lead to prolonged labor or other complications during delivery.

Impact on Fertility

There’s also evidence suggesting that long-term use of Advil can affect fertility in women. It’s essential to discuss these risks with your doctor if you’re trying to conceive.

Medication Interactions

Advil can interact with other medications, amplifying side effects or diminishing the effectiveness of either drug. This is particularly important for individuals taking blood thinners, certain antidepressants, or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Considerations for Elderly Patients

Older adults are generally more sensitive to the effects of medications like Advil. They face a higher risk of gastrointestinal bleeding and kidney damage, making careful monitoring essential.


Advil, while commonly used and generally safe for short-term relief, poses several risks when used long-term. These risks include serious gastrointestinal issues, increased cardiovascular risks, potential kidney and liver damage, allergic reactions, and interactions with other medications. If you’re considering long-term use of Advil, it’s important to discuss these risks with your healthcare provider and explore alternative treatment options. Your health and safety should always be the top priority when managing pain or inflammation.

Similar Posts